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Guinea Pig Peeing Blood – Ask A Guinea Pig Vet

Guinea Pig Peeing Blood - Ask A Guinea Pig Vet

Reviewed by Carol Dunham

Seasoned Pet owner and enthusiast, Content Reviewer at

As a seasoned guinea pig owner, I’ve seen those alarming red stains in the cage far too often. My heart sinks every time. But over the years caring for countless pigs, I’ve learned when to panic and when to relax. In this complete guide, I’ll share everything I know about the causes, symptoms, diagnosis, and treatment of blood in guinea pig urine.

With insights direct from exotic animal vets, you’ll understand why guinea pigs sometimes pee blood, how to get the right diagnosis fast, and what you can do to help your piggie recover and stay healthy. By the end, you’ll be able to assess those scary sights of red with confidence, catch problems early, and take the best action for your furry friend. Whether you’re looking to soothe your worries or need to spur yourself into action, you’ll find vet-approved advice here to handle you Guinea Pig Peeing Blood. Let’s take this step-by-step to determine what’s wrong and how to make it right.

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What Causes Blood in Guinea Pig Urine?

There are several potential reasons why your guinea pig may have blood in its urine:

Urinary Tract Infection (UTI)

One of the most common causes is a urinary tract infection or UTI. Guinea pigs’ short stature and proximity to soiled bedding puts them at higher risk for UTIs. Bacteria travels up the urethra into the bladder, causing inflammation and bleeding. Symptoms include painful urination, blood in urine, lack of appetite, lethargy and fever. Without antibiotic treatment, the infection can spread to the kidneys. Females are especially prone due to their shorter urethras.

Bladder/Kidney Stones

Gritty deposits of minerals like calcium can crystallize into stones in the kidneys or bladder, causing irritation, blockages and bleeding. Guinea pigs’ urine tends to be alkaline, allowing calcium to precipitate out. Diet and genetic factors also play a role. Signs include straining, bloody urine, weight loss, tooth grinding, and biting at the hindquarters. Stones usually require surgical removal and dietary changes to prevent recurrence.


General inflammation of the bladder, with or without a bacterial infection, can lead to bleeding. Poor hygiene, obesity, lack of exercise and stones increase the risk of cystitis. Symptoms mirror those of UTIs and stones. Anti-inflammatories, antibiotics and painkillers help resolve cystitis when caught early.

Uterine Infection (Pyometra)

Unspayed females may develop pyometra, a bacterial infection of the uterus. Pus and debris build up in the infected organ, sometimes leaking blood into the urinary tract. Guinea pigs become lethargic, lose their appetite and show signs of pain. Emergency spay surgery and antibiotics are required. Spaying healthy guinea pigs prevents pyometra.

Ovarian Cysts

Fluid-filled masses on the ovaries of unspayed females occasionally twist, rupture or put pressure on surrounding organs. This can cause abdominal swelling, appetite loss, aggression and bloody urine. Surgery removes the cysts. Spaying is recommended to avoid recurrence.


Various cancers, especially lymphatic cancers, can disrupt organs and lead to bloody urine in guinea pigs. Enlarged lymph nodes, lumps on the skin and progressive weight loss may indicate cancer. Surgical removal of tumors can prolong life. But cancer treatment options are limited in guinea pigs.

Physical Trauma

Falls, bites and other injuries, even if not directly involving the urinary tract, can sometimes damage the kidneys or bladder and cause bleeding. Any blunt trauma to your guinea pig warrants an immediate vet visit to check for internal damage.

What are the Symptoms of Blood in Guinea Pig Urine?

Blood in Guinea Pig Urine

Look for these signs of possible blood in your guinea pig’s urine:

  • Red, pink, or brown tinge to the urine, especially when dry
  • Straining or squeaking when urinating
  • Lethargy, lack of appetite, or weight loss
  • Hunched posture suggesting pain
  • Excessive licking or biting at the hindquarters
  • Wet fur around bottom and belly
  • Strong odor to urine or cage

How is Blood in the Urine Diagnosed?

Start by collecting a fresh urine sample if possible, by placing your guinea pig on a clean towel or sterile container after providing hydrating veggies like cucumber.

Your vet will ask about your guinea pig’s diet, environment, and symptoms. They’ll thoroughly examine your pet, feeling for bladder stones or an enlarged uterus, noting signs of pain, checking vitals and weight.

Diagnostic tests confirm blood in the urine and reveal underlying issues:

  • Urinalysis checks for blood cells, bacteria, and crystals
  • Urine culture identifies any infectious organisms
  • Blood work evaluates kidney function
  • Imaging (x-rays or ultrasound) visualizes stones, tumors, cysts
  • Exploratory surgery directly examines the bladder and reproductive tract

How is Bloody Urine Treated in Guinea Pigs?

Guinea Pig Treatment

Treatment targets the specific cause of bleeding:

  • Urinary tract infections require antibiotic therapy for 2-4 weeks to fully resolve. Pain medication brings relief while anti-inflammatories reduce swelling.
  • Bladder stones necessitate surgery for removal, as well as diet changes to prevent recurrence. Stones in kidneys or ureters are more difficult to take out.
  • Cystitis is treated with antibiotics, anti-inflammatory meds, and painkillers. Underlying causes like stones must also be addressed.
  • Pyometra and ovarian cysts call for emergency spay surgery to remove infected uteruses and cystic ovaries. Supportive care prevents shock.
  • Cancer may be surgically removed if a single tumor is present and the guinea pig is healthy enough to withstand anesthesia. But prognosis is generally poor.
  • Physical injury requires repairing damaged tissues and organs, IV fluids, pain control, and monitoring for complications like infections.

Stopping bloody urine quickly is crucial. Guinea pigs can deteriorate rapidly. But even after symptoms resolve, continue full treatment regimens to prevent recurrence.

How Can I Prevent Blood in My Guinea Pig’s Urine?

You can reduce the risks of hematuria through proper guinea pig care:

  • Choose a high quality diet with unlimited timothy hay, limited pellets, and 1/4 cup vegetable mixture per pig daily. Avoid excess calcium.
  • Give filtered water in clean bottles. Increase hydration to promote urinary tract health. Offer some diluted cranberry juice.
  • Thoroughly clean and disinfect housing at least weekly, using fleece liners and frequent spot cleaning to keep guinea pigs dry.
  • Schedule regular exercise and floor time. Lack of activity leads to obesity and bladder problems.
  • Monitor urine color and output daily. Note any unusual changes and bring guinea pigs in for prompt vet exams.
  • Consider spaying female guinea pigs to protect against ovarian cysts and pyometra after 4-6 months of age.
  • Handle guinea pigs carefully to prevent falls and injuries. Supervise playtime with cage mates.
  • Perform weekly at-home health checks for lumps, weight changes, and signs of illness. Update your vet at annual exams.
  • Find an experienced exotic vet and establish a relationship before emergencies occur. Stay vigilant for any symptoms requiring prompt veterinary attention.

While startling, blood in guinea pig urine often results from treatable conditions like UTIs and bladder stones when addressed quickly. With attentive care and prevention methods, you can keep your guinea pig’s urinary system healthy and enjoy many happy, blood-free years together. Monitor urine daily, learn the signs of trouble, and don’t hesitate to involve your vet at the first hint of blood.

When To Ask A Guinea Pig Vet Online

Ask A Guinea Pig Vet Online

If you need to consult a veterinarian about your guinea pig’s bloody urine, I highly recommend using JustAnswer. Their experienced vets provide personalized advice 24/7 to distressed pet owners like us. It’s the quickest and most affordable way to get expert guidance about your unique guinea pig’s situation from the comfort of home. I’m grateful we have access to such a valuable online resource for those times when every minute counts in safeguarding our beloved guinea pigs’ health.


Detecting blood in your guinea pig’s urine early, accurately diagnosing the cause, and pursuing the appropriate treatment plan with your vet’s guidance can resolve many troubling cases of hematuria. Stay alert for symptoms, monitor your guinea pig’s health diligently, and cultivate strong preventive care habits. With a bit of knowledge and vigilance, you can keep your small pet’s urinary system in top shape for years to come.

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